Laser vaporous by-products (plume) have been shown to contain fine particulate matter which creates anatomically identifiable lesions when chronically inspired. The particulates are commonly minuscule with mean aerodynamic diameters of 0.1 – 0.3 micron. Careful and continuous evacuation of the smoke with high flow rate evacuation systems equipped with sophisticated filtration systems have been shown to protect animal models breathing filtered plume.
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